The Chan Zuckerberg Initiative operates Biohubs in San Francisco, New York, and Chicago, integrating scientists, engineers, and AI experts to develop technologies in dynamic imaging, immune cell reprogramming, and bioengineering for biomedical research. It awards grants to researchers and organizations focused on areas such as single-cell biology and essential open source software for science, having disbursed $7.22 billion since 2015. CZI makes venture investments in impact-focused companies addressing challenges in science, education, and justice, totaling nearly $300 million invested. Founded in 2015 by Priscilla Chan, co-CEO and trained pediatrician with degrees from Harvard and UCSF, and Mark Zuckerberg, co-CEO and founder of Meta.