OneSixOne Ventures is a Gainesville, Florida-based (with strong presence in Miami and Seattle) pre-seed and early-stage venture capital firm founded in 2017 by Justis Mendez and Pablo Casilimas, specializing in investments in dual-use technologies, cloud and AI infrastructure, enterprise software, B2B SaaS, and government technology startups.

The firm stands out for its community-driven approach, originating from hosting curated networking events across underrepresented ecosystems to connect founders with investors and partners, while providing hands-on support and ecosystem development from Florida to the Pacific Northwest.

With approximately $4 million in assets under management as of 2025 and a portfolio of around 21 companies, notable investments include Clockout (fintech), Nerd Apply (database software), Agentuity, Sunthetics, and early bets like Rain AI (AI chips), focusing on high-potential pre-seed opportunities often sourced through their extensive event network and warm introductions.