Genome Project-Write (GP-write) is an international consortium of research organizations, scientists, ethicists, and policymakers that develops scientific, technical, ethical, and governance frameworks for genome-scale engineering in microbes, plants, animals, and humans. The project aims to reduce the cost of genome synthesis and assembly by three orders of magnitude while creating design, editing, testing, and regulatory tools for responsible whole-genome engineering. It involves over 200 scientists from more than 60 institutions worldwide and emphasizes integration of ethical, legal, and social implications from the outset. GP-write builds on the Human Genome Project by advancing from genome reading to writing capabilities. Activities include producing white papers on applications like virus-resistant cells and engineered blood, hosting international workshops, and funding pilot projects. The consortium was launched in Boston in May 2016 with a steering committee chaired by George Church of Harvard Medical School.