F-Prime Capital is a global venture capital firm that invests in life sciences companies developing therapeutics and medtech, technology firms building enterprise software, fintech, and frontier tech, as well as healthtech and services, and crypto ventures. It backs exceptional teams from early stage through later stages, with a portfolio exceeding 400 companies across the Americas, Europe, and Asia, including over 35 companies started from scratch. The firm manages $4.8 billion in assets under management without reliance on outside limited partners. Headquarters are located at 1 Main Street, 13th Floor in Cambridge, Massachusetts, with an additional office at 33 Foley Street in London. President and Senior Managing Partner Stephen Knight, MD, joined in 2003 following senior roles in biotechnology companies, consulting, and research positions at AT&T Bell Laboratories, the National Institutes of Health, and Yale University. Managing Partner David Jegen leads the tech fund, investing in fintech and enterprise software after serving as VP at Into Networks, executive positions at Cisco Systems, and early roles at J.P. Morgan and BCG. Managing Partner Jon Lim directs healthtech and services investments, having joined in 2011 after principal roles at Polaris Partners and Summit Partners, plus work at Medtronic.